Scarlets centre Joe Roberts will make his first professional start on the wing when Wales tackle Guinness Six Nations title contenders England in Cardiff.
Roberts replaces Tom Rogers, who suffered a fractured thumb during the early stages of Wales’ 35-29 defeat against Scotland at Murrayfield.
Wales’ interim head coach Matt Sherratt has made one other change from that game, with Aaron Wainwright featuring at blindside flanker.
Wainwright’s call-up means captain Jac Morgan switches to his more familiar openside role and Leicester flanker Tommy Reffell drops to the replacements’ bench.
Roberts impressed on the wing after going on for Rogers in Edinburgh to win his fourth cap and he has won Sherratt’s vote ahead of other options such as starting Gloucester back Josh Hathaway or moving Max Llewellyn from midfield.